Melanin synthesis and regulation in vivo and commonly used melanin inhibitors from natural products and traditional Chinese medicine / 中国中药杂志

Melanin is an important factor affecting human skin color. This study defines its synthetic pathways and regulatory pathways have the practical significance for the treatment of diseases caused by pigmentation problems, such as chloasma. Besides, it also provides a theoretical basis for screening out melanin inhibitors and developing whitening and freckle products. At present, the melanin inhibitors used in whitening and freckle products mainly come from natural products and traditional Chinese medicine. This article first introduces the melanin biosynthesis pathway with tyrosinase as the core, defines the synthesis, transport and catalytic activity of tyrosinase as the three key factors affecting melanin synthesis, and then reviews two common types of melanin inhibitors, namely tyrosinase synthesis inhibitors and tyrosinase inhibitors derived from natural products and traditional Chinese medicine. This article provides guidance for the development of new melanin inhibitors, and puts forward the idea for combining and synergizing inhibitors according to different mechanisms, in order to develop new whitening formulas.

Chemical constituents from Garcinia multiflora fruits / 中草药

Objective To study the chemical constituents of the fruits of Garcinia multiflora. Methods The constituents were isolated and purified by silica gel column chromatography and semipreparative HPLC, and their structures were elucidated by means of spectroscopic analyses. Results Six compounds were obtained and identified as multiflorone A (1), sargaol (2), δ-tocotrienol (3), luteolin (4), 1,3,6,7-tetrahydroxyxanthone (5), terephthalic acid bis (2-ethyl-hexyl) ester (6). Conclusion Compound 1 is a new homoadamantyl type phloroglucinol, and compounds 2, 3 and 6 are isolated from this plant for the first time.